Influence of Post-Irradiation Medication with Antibiotic JM-57h on Survival Time in Mice.

Abstract

Antibiotic JM-57h, a wide spectrum agent, has been used to combat post-irradiation infection without significantly increasing the total no. of survivors. In the group medicated daily an increase in the ST50 day was noted. Medication must be started during the 1st post-irradiation wk. before massive bacteremia occurs, otherwise such therapy will not be beneficial. At a dose of 0.1 of its LD50, antibiotic JM-57h was well tolerated and produced no fatalities or untoward reactions in CF-1 strain mice.