A STUDY OF THE PROPERTIES OF THE FREE AMINO ACID POOL AND ENZYME SYNTHESIS IN YEAST
Open Access
- 20 March 1955
- journal article
- research article
- Published by Rockefeller University Press in The Journal of general physiology
- Vol. 38 (4), 549-573
- https://doi.org/10.1085/jgp.38.4.549
Abstract
A study has been made of the distribution and properties of the free amino acid pool in yeast. The depletion of the pool was found to depend upon the energy source used, conditions of growth and the nature of the exogenous nitrogen sources. Pool levels could be restored either by an internal replenishment mechanism or by various nitrogen sources. In the absence of internal replenishment a strong positive correlation was established between the ability of nitrogen compounds to support free glutamic acid synthesis and enzyme-synthesizing capacity. Amino acid assimilation by nitrogen-starved yeast was studied and compared with other organisms. The significance of these results for the problem of enzyme and protein synthesis in yeast is discussed.Keywords
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