A Dose-Response Equation for the Invasion of Micro-Organisms

Abstract

The author discusses the problem of estimating the LD50 of pathogenic microorganisms administered to host animals. A linear relationship between log survival and dose is assumed and tables are given for obtaining the max. likelihood estimate and its standard error. Several expts. are presented and the results of computations are compared with probit analysis. The evidence demonstrates no difference between the 2 models. Optimum choice of doses is discussed.