Role of'Intercellular'Matrix in Aggregation of Mammalian Cells

Abstract

Summary 1. Partial and slow dissociation of mouse liver in vitro that occurs on treatment with phosphate indicates a K+ independent factor involved in aggregation of cells. 2. The presence of low concentrations of hy-drocortisone during dissociation in phosphate causes the aggregation into long fibers of an intercellular material. 3. Dissociation effected with phosphate has been attributed to a'de-stabilization'of the intercellular matrix.