Cerebrospinal Irradiation of Burkitt's Lymphoma: Failure in preventing central nervous system relapse
Open Access
- 1 January 1977
- journal article
- clinical trial
- Published by Taylor & Francis in Acta Radiologica: Therapy, Physics, Biology
- Vol. 16 (3), 225-231
- https://doi.org/10.3109/02841867709133941
Abstract
Twenty-two patients with Burkitt's lymphoma in complete remission induced by either cyclophosphamide or a combination of cyclophosphamide, oncovin and methotrexate were randomized to receive or not to receive prophylactic cerebrospinal irradiation. Six of 11 irradiated patients relapsed with tumour of the central nervous system as compared to 4 of 11 controls. Relapse frequency appeared to be related to stage of disease on admission. It is concluded that irradiation does not prevent relapse.Keywords
This publication has 8 references indexed in Scilit:
- Treatment of Burkitt's lymphoma: Randomized clinical trial of single-agent versus combination chemotherapyInternational Journal of Cancer, 1976
- POSTIRRADIATION SYNDROME AND EEG FINDINGS IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKAEMIAActa Paediatrica, 1975
- Cell kinetics in Burkitt lymphomaEuropean Journal of Cancer (1965), 1974
- Prevention of central nervous system leukemia by irradiationCancer, 1973
- A comparative study of central nervous system irradiation and intensive chemotherapy early in remission of childhood acute lymphocytic leukemiaCancer, 1972
- Intrathecal Chemotherapy in Burkitt's LymphomaBMJ, 1971
- Conventional and Superfractionated Radiation Therapy in Burkitt's LymphomaActa Radiologica: Therapy, Physics, Biology, 1971
- Meningeal LeukemiaPublished by American Medical Association (AMA) ,1968