ANALYSIS OF THE FACTORS INVOLVED IN GASTRIC MOTOR INHIBITION BY FATS

Abstract

Gastric motor inhibition from ingested fats was generally ascribed to nerve reflexes until Farrell and Ivy demonstrated its occurrence in the denervated gastric pouch. The present study confirms and extends this observation and indicates that a humoral factor is also exclusively responsible for the gastric inhibition following fat ingestion in the entire stomach pouch with blood vessels stripped and the stomach denervated by vagot-omy, splanchnectomy and celiac ganglionectomy. Contact of fat with the mucosa of the digestive tract apparently produces the specfic gastric inhibitory humoral factor, for intravenously administered fats, soaps, glycerine, secretin or cholecystokinin are ineffective. Initiation of the humoral factor (and nervous factor if involved) occurs from the upper intestine but not from the stomach; gastric inhibition follows introduction of fat into the intestine of dogs with an entire stomach pouch or with pylorus obstructed, but fat in the pouch of the entire stomach or in the auto-transplanted gastric pouch does not modify gastric motility.