Action of Propranolol in Mania: Comparison of Effects of the d- and the l-stereoisomer
- 1 July 1979
- journal article
- research article
- Published by Georg Thieme Verlag KG in Pharmacopsychiatry
- Vol. 12 (04), 295-304
- https://doi.org/10.1055/s-0028-1094624
Abstract
The antimanic action of high doses of the .beta.-receptor blocking agent propranolol was studied using a double-blind placebo controlled ABA design. For comparison, the d-stereoisomer (which is practically devoid of .beta.-blocking activity) was used. There were 6 trials with d-propranolol and 6 with the racemic mixture. From dose-effect relations it seems that the d-stereoisomer is about half as effective against manic syndromes as the racemic mixture. Apparently the antimanic action of propranolol is partially due to a mechanism independent of its .beta.-blocking action.This publication has 7 references indexed in Scilit:
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