Age-dependent prevalence of BK virus IgG and IgM antibodies measured by enzyme-linked immunosorbent assays (ELISA)
- 1 February 1986
- journal article
- research article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 96 (3), 523-528
- https://doi.org/10.1017/s0022172400066328
Abstract
SUMMARY: Enzyme immunoassays (ELISA) have been developed for the detection of BK virus IgG- and IgM-antibodies. Specific IgG is detected by an antigen-coated solid phase test; IgM by an antibody capture method.These methods have been used to study the age-distribution of BK virus antibodies in Troms county in Northern Norway. The serum panels tested were: (a) 60 sera from paediatric patients aged 0–1 year; (b) 220 sera from healthy persons aged 1–82 years; (c) 74 sera from healthy blood donors; (d) 107 sera from healthy pregnant women.The age-distribution of BKV-IgG antibodies showed that primary infections took place predominantly between the ages of 1 and 6 years, and that there were no sex differences, either in the age-specific prevalence or in the level of BKV-IgG.We found no significant differences in the prevalence of BKV-IgM antibodies in healthy children and adults and pregnant women. BKV-IgM was detected in 26 of the 461 sera tested (5·6%).This publication has 19 references indexed in Scilit:
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