A routine of using several different anti-cancer agents together has been established as being an effective and practical way of treating advanced cancer. Sequentially radiation therapy can be given to maintain or increase the initial help of chemotherapy. The anti-cancer drugs may in some cases be continued with and/or after completion of radiation to maintain the benefits. Partial or total surgical excision of cancer treated first or afterward by chemotherapy and radiation has added to disease control. Fifty-nine advanced cancers have been treated in this fashion by the authors, giving objective and subjective benefits of over six months duration, many for much longer than six months.