CHOICE BETWEEN FOOD AND HEROIN: EFFECTS OF MORPHINE, NALOXONE, AND SECOBARBITAL
- 1 May 1981
- journal article
- research article
- Published by Wiley in Journal of the Experimental Analysis of Behavior
- Vol. 35 (3), 335-351
- https://doi.org/10.1901/jeab.1981.35-335
Abstract
Baboons responded on a choice task on which discrete trials involved choosing between an intravenous injection of heroin (.32 or 1.0 mg/kg) or the availability of food pellets. An intertrial interval of three hours followed the completion of each trial. Under baseline conditions baboons consistently completed the eight available trials each day. Typically, animals chose heroin on three or four trials a day and food on the remaining trials. Animals tended to space the selection of heroin rather than choosing heroin on consecutive trials. A series of single-day experimental manipulations was undertaken to characterize performance further. Manipulation of the heroin dose produced shifts in the relative frequency of choosing the drug option which were inversely related to dose. Manipulation of number of pellets per food trial produced little change in distribution of choices. Noncontingent administration of morphine produced dose-related decreases in relative frequency of heroin choices, and at higher doses decreased the number of trials completed. Noncontingent naloxone produced dose-related increases in the relative frequency of heroin choices. Noncontingent secobarbital had no effect on distribution of choices, and high doses reduced the number of trials completed per day. The results suggest that morphine and naloxone produce shifts in this choice behavior by selectively interacting with the reinforcing properties of the option involving heroin.Keywords
This publication has 17 references indexed in Scilit:
- CONTINUOUS INTRAVENOUS NALTREXONE EFFECTS ON MORPHINE SELF-ADMINISTRATION IN RHESUS-MONKEYS1978
- Changes in morphine self-administration in rats induced by prostaglandin E1 and naloxoneProstaglandins, 1976
- Discrete-trial choice procedure: effects of naloxone and methadone on choice between food and heroin.1975
- Effects of naloxone subcutaneous pellets on relapse to morphine self-administration in post-addict rats.1975
- Behavioral functions of narcotic antagonists: response-drug contingenciesPublished by Springer Nature ,1975
- Addiction to secobarbital and chlordiazepoxide in the rhesus monkey by means of a self-infusion preference procedurePsychopharmacology, 1972
- Nalorphine-induced changes in morphine self-administration in rhesus monkeys.1971
- Morphine: Conditioned Increases in Self-Administration in Rhesus MonkeysScience, 1969
- Factors affecting voluntary morphine intake in self-maintained addicted ratsPsychopharmacology, 1964
- Experimental Morphine Addiction: Method for Automatic Intravenous Injections in Unrestrained RatsScience, 1962