Ultraviolet irradiation of platelet concentrate abrogates lymphocyte activation without affecting platelet function in vitro
- 1 November 1985
- journal article
- research article
- Published by Wiley in Transfusion
- Vol. 25 (6), 547-550
- https://doi.org/10.1046/j.1537-2995.1985.25686071428.x
Abstract
We studied the effect of ultraviolet (UV) radiation on platelet concentrates. Samples irradiated at 310 nm for 30 minues at a dose of 1782 J per m2 showed no loss of platelet function in vitro as determined by adenosine diphosphate, collagen, or ristocetin-induced aggregation. Lymphocytes isolated from irradiated units were unable to act as responders or stimulators in a mixed-lymphocyte reaction. These data suggest that UV radiation of platelet concentrates may result in a cell suspension that is unable to evoke an immunological response.Keywords
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