Evidence for the Neuropeptide Cholecystokinin as an Antagonist of Opiate Analgesia
- 20 January 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 219 (4582), 310-312
- https://doi.org/10.1126/science.6294831
Abstract
The endogenous neuropeptide cholecystokinin, when administered systemically or perispinally, potently antagonizes opiate analgesia produced by foot shock and morphine. Nonopiate foot-shock analgesia is not reduced by this neuropeptide. The spinal cord appears to be a critical site of cholecystokinin action. These experiments suggest a physiological role for cholecystokinin as a specific opiate antagonist in analgesia-mediating systems. A similar mode of action may explain other behavioral effects of cholecystokinin, such as suppression of food intake.Keywords
This publication has 22 references indexed in Scilit:
- Organization of Endogenous Opiate and Nonopiate Pain Control SystemsScience, 1982
- Endogenous opiates: 1980Peptides, 1981
- Stress-Induced Eating Is Mediated Through Endogenous OpiatesScience, 1980
- Morphine addiction and withdrawal alters brain peptide concentrationsLife Sciences, 1980
- Peptidergic neuronesNature, 1980
- On the specificity of naloxone as an opiate antagonistLife Sciences, 1979
- Adrenocortical stimulation by a cholecystokinin preparation in the ratLife Sciences, 1979
- Cholecystokinin in the Brains of Obese and Nonobese MiceScience, 1979
- Unsulfated C-terminal 7-peptide of cholecystokinin: A new ligand of the opiate receptorBiochemical and Biophysical Research Communications, 1978
- Neuropeptides: Influence of acute and chronic effects of opiatesPsychoneuroendocrinology, 1977