OBSERVATIONS ON THE MODE OF ACTION OF PIPERIDINOMETHYLBENZODIOXANE (933F)

Abstract

The dioxane derivative 933F markedly reduces the responses of the salivary gland to injected adrenalin. In spite of the probability that the nerves end outside the effector cells, the responses to sympathetic nerve stimuli are less seriously impaired. After the nictitating membrane or blood pressure has responded fully to adrenalin, the injection of 933F rapidly curtails the response. The destruction of adrenalin in vitro is significantly accelerated by 933F. Observations are shown to make it difficult to explain the action of 933F by changes of cellular permeability. Some other plausible explanations of the action of 933F are discussed.