A study of the effect of spring flooding on the movements of a marked population of white-footed mice, Peromyscus leucopus noveboracensis, was conducted in Wood County, Ohio. The study area included 0.71 acre and was flooded on two separate occasions; once the leaf litter was so saturated as to be uninhabitable. Live traps and nest boxes were used to obtain recapture data from which home ranges of the 19 resident mice were calculated by the boundary-strip method. Home ranges averaged 0.19 acre for resident males and 0.20 acre for females. Flooding did not cause enlargement of home ranges, but did lead to increased use of the peripheral portions of the established home range and above-ground nesting sites. Flooding did not seem to inhibit movements of the mice within the area nor was it detrimental to their numbers.