Xenogeneic Cell Therapy: Current Progress and Future Developments in Porcine Cell Transplantation
Open Access
- 1 November 1998
- journal article
- review article
- Published by SAGE Publications in Cell Transplantation
- Vol. 7 (6), 525-539
- https://doi.org/10.1177/096368979800700603
Abstract
The multitude of distinct cell types present in mature and developing tissues display unique physiologic characteristics. Cellular therapy is a novel technology with the promise of utilizing this diversity to treat a wide range of human degenerative diseases. Intractable diseases, disorders, and injuries are characterized by cell death or aberrant cellular function. Cell transplantation can replace diseased or lost tissue to provide restorative therapy for these conditions. The limited use of cell transplants as a basis for current therapy can, in part, be attributed to the lack of available human cells suitable for transplantation. This has prevented further realization of the promise of cell transplantation as a platform technology. Accordingly, cell-based therapies such as blood transfusions, for which the cells are readily available, are a standard part of current medical practice. Despite numerous attempts to expand primary human cells in tissue culture, current technological limitations of this approach in regard to proliferative capacity and maintenance of the differentiated phenotype has prevented their use for transplantation. Further, use of human stem cells for the derivation of specific cell types for transplantation is an area of future application with great potential, but hurdles remain in regard to deriving and sufficiently expanding these multi-potential cells. Thus, it appears that primary cells are at present a superior source for transplantation. This review focuses on pigs as a source of a variety of primary cells to advance cell therapy to the clinic and implement achievement of its full potential. We outline the advantages and disadvantages of xenogeneic cell therapy while underscoring the utility of transplantable porcine cells for the treatment of human disease. © 1998 Elsevier Science Inc.Keywords
This publication has 102 references indexed in Scilit:
- Transplantation of Fetal Neocortex Ameliorates Sensorimotor and Locomotor Deficits Following Neonatal Ischemic–Hypoxic Brain Injury in RatsExperimental Neurology, 1997
- Lumbar transplants of immortalized serotonergic neurons alleviate chronic neuropathic painPain, 1997
- Delayed xenograft rejectionImmunology Today, 1996
- Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibresNature Medicine, 1995
- A role for CD95 ligand in preventing graft rejectionNature, 1995
- Bilateral fetal nigral transplantation into the postcommissural putamen in Parkinson's diseaseAnnals of Neurology, 1995
- Pigment cell transplantation for treatment of vitiligo: A progress reportJournal of the American Academy of Dermatology, 1994
- PROTECTION OF PIG KIDNEY (PK15) CELLS FROM THE CYTOTOXIC EFFECT OF ANTI-PIG ANTIBODIES BY α-GALACTOSYL OLIGOSACCHARIDES1Transplantation, 1994
- A DIABETIC RABBIT MODEL FOR PIG ISLET XENOTRANSPLANTATION1Transplantation, 1993
- Interaction of the natural anti-Gal antibody with α-galactosyl epitopes: a major obstacle for xenotransplantation in humansImmunology Today, 1993