Shared antigenic determinants between human brain and human T-cell line.

  • 1 December 1974
    • journal article
    • Vol. 18 (4), 491-8
Abstract
Rabbits were immunized with MOLT cells (T cells) and RPMI number 1788 (B cells) to get respective antisera. These sera were absorbed with human liver, human brain, or various B cells (RPMI number 1788, SOMMER-B cell, B-35M cells and B-411 cells). The results indicate that the cytotoxicity of rabbit anti-MOLT serum against MOLT cells could be absorbed to some extent with human liver and various B cells but not completely. Human brain could completely absorb anti-MOLT activity from rabbit anti-MOLT serum. Human brain could not remove anti-B-cell activity from rabbit anti-RPMI number 1788 (B cells). Rat brain did not remove anti-MOLT activity from anti-MOLT serum.