Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
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- 7 June 2009
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 12 (7), 826-828
- https://doi.org/10.1038/nn.2349
Abstract
Mutations in LRRK2 can cause Parkinson's disease. The authors create a transgenic mouse model of LRRK2 that recapitulates several cardinal features of the disease. Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics.Keywords
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