Role of Ia‐Positive Cells in the Lymphocyte Responses to Yersinia
- 1 August 1984
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 20 (2), 141-147
- https://doi.org/10.1111/j.1365-3083.1984.tb00987.x
Abstract
Activation of T lymphocytes by an antigen requires joint recognition of the antigen and the class-II HLA determinants on the membrane of the antigen-presenting cells (APC). Patients with reactive arthritis exhibit a depressed lymphocyte transformation response to Yersinia, suggesting a possible immunoregulatory disturbance in these patients. In this study the role of Ia (class-II HLA antigen)-positive APC in the lymphocyte response to a complex antigen, whole Yersinia bacterium, was evaluated. The results demonstrate that Ia-positive cells are necessary for the T-lymphocyte response to Yersinia. The role of APC in the pathogenesis of reactive arthritis is discussed.This publication has 32 references indexed in Scilit:
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