Simple RNA enzymes with new and highly specific endoribonuclease activities
- 1 August 1988
- journal article
- Published by Springer Nature in Nature
- Vol. 334 (6183), 585-591
- https://doi.org/10.1038/334585a0
Abstract
In vitro mutagenesis of sequences required for the self-catalysed cleavage of a plant virus satellite RNA has allowed definition of an RNA segment with endoribonuclease activity. General rules have been deduced for the design of new RNA enzymes capable of highly specific RNA cleavage, and have been successfully tested against a new target sequence.Keywords
This publication has 25 references indexed in Scilit:
- Construction of a series of several self‐cleaving RNA duplexes using synthetic 21‐mersFEBS Letters, 1988
- Self-cleavage of virusoid RNA is performed by the proposed 55-nucleotide active siteCell, 1987
- The Chemistry of Self-Splicing RNA and RNA EnzymesScience, 1987
- Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sitesCell, 1987
- Self-cleaving transcripts of satellite DNA from the newtCell, 1987
- Non-enzymatic cleavage and ligation of RNAs complementary to a plant virus satellite RNANature, 1986
- Pb(II)-catalysed cleavage of the sugar–phosphate backbone of yeast tRNAPhe—implications for lead toxicity and self-splicing RNANature, 1983
- Construction and characterization of the chloramphenicol-resistance gene cartridge: A new approach to the transcriptional mapping of extrachromosomal elementsGene, 1982
- Oligomers of avocado sunblotch viroid are found in infected avocado leavesFEBS Letters, 1982
- Nucleotide sequence analysis of the chloramphenicol resistance transposon Tn9Nature, 1979