Tobramycin and Gentamicin Concentrations in the Serum of Normal and Anephric Patients
- 1 January 1973
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 3 (1), 125-129
- https://doi.org/10.1128/aac.3.1.125
Abstract
The serum half-life of tobramycin was found to be the same as that of gentamicin in patients with similar renal function. The values ranged from 2 hr in normal volunteers to 53.4 hr in anephric patients. Both drugs were readily removed from the serum by the Kiil artificial kidney, with a 70% reduction in serum concentrations during a 12-hr dialysis period.Keywords
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