A comparison of the efficacy of ketotifen (HC 20‐511) with sodium cromoglycate (SCG) in skin test positive asthma.
- 1 November 1980
- journal article
- clinical trial
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 10 (5), 473-476
- https://doi.org/10.1111/j.1365-2125.1980.tb01791.x
Abstract
1 Ketotifen (HC 20‐511 Sandoz) 1 mg twice daily for 12 weeks was found to be equivalent to sodium cromoglycate (SCG) 20 mg four times daily for 12 weeks in 35 skin test positive asthmatic patients in a randomised double‐blind cross‐over study. 2 No statistically significant difference between the two drugs in mean values for daily peak flow rates, diary card scores and spirometry at monthly visits was demonstrated. 3 Treatment failures as judged by severe asthma requiring withdrawal from the trial or addition of short courses of prednisone occurred in three patients on each drug. 4 Sedation was noted by 10 patients onHC 20‐511 and 5 on SCG. 5 Weight loss was noted in those patients on SCG, but not those on HC 20‐511.Keywords
This publication has 5 references indexed in Scilit:
- A placebo‐controlled trial of ketotifen (HC 20‐511, Sandoz) in allergen induced asthma and comparison with disodium cromoglycateClinical and Experimental Allergy, 1979
- Clinical investigation of agents with prophylactic anti‐allergic effects in bronchial asthma*Clinical and Experimental Allergy, 1978
- Comparison between ketotifen and DSCG in bronchial challengeClinical and Experimental Allergy, 1978
- The pharmacological properties of a new, orally active antianaphylactic compound: ketotifen, a benzocycloheptathiophene.1978
- Long-term Study of Disodium Cromoglycate in Treatment of Severe Extrinsic or Intrinsic Bronchial Asthma in AdultsBMJ, 1972