Amino Acids and Peptides. XXXIV. Synthesis of Mouse Metallothionein I.(1). Synthesis of Dotriacontapeptide Corresponding to C-Terminal Sequence 30-61 (.ALPHA.-Fragment) of Mouse Metallothionein I and Related Peptides and Examination of Their Heavy Metal-Binding Properties.

Abstract

The dotriacontapeptide corresponding to the C-terminal sequence of mouse metallothionein (MT) I and related peptides which contain Cys-X-Cys-Cys (X : amino acid residue except for Cys) sequence were synthesized by the conventional solution method employing the HF deprotection method and their heavy metals (Cd²⁺, Cu²⁺ and Cu⁺)-binding properties were examined.