Hodgkin's Disease and Acute Leukaemia A Clinical and Cytogenetic Study

Abstract

Three patients developing acute myeloid leukemia after treatment for Hodgkin''s disease are reported. They appeared among 153 patients treated since 1971. All 3 patients were treated with high voltage radiation of large target volumes as well as multiple drug chemotherapy. In 2 of the patients chromosomal analyses of the leukemic bone marrow cells were performed by modern banding techniques. Chromosome abnormalities were found in both patients. The value of cytogenetic analysis with the new staining techniques for elucidating the mechanism of leukemogenesis in Hodgkin''s disease is discussed.