Mutation induction in chinese hamster V79 cells by two vinyl chloride metabolites, chloroethylene oxide and 2‐chloroacetaldehyde
- 15 October 1975
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 16 (4), 639-644
- https://doi.org/10.1002/ijc.2910160414
Abstract
Chloroethylene oxide and 2‐chloroacetaldehyde, two possibly carcinogenic metabolites of vinyl chloride in mammals, caused a dose‐dependent induction of 8‐azaguanine‐and ouabain‐resistant mutants in Chinese hamster V79 cells in vitro. Up to one‐hundredfold higher concentrations of 2‐chloroethanol or monochloroacetic acid, a urinary vinyl chloride metabolite in rats and man, were inactive.Keywords
This publication has 20 references indexed in Scilit:
- Mutagenicity of vinyl chloride, chloroethyleneoxide, chloroacetaldehyde and chloroethanolBiochemical and Biophysical Research Communications, 1975
- Human, rat and mouse liver‐mediated mutagenicity of vinyl chloride in S. typhimurium strainsInternational Journal of Cancer, 1975
- CHROMOSOME ABERRATIONS IN WORKERS EXPOSED TO VINYL CHLORIDEThe Lancet, 1975
- 2-haloethanols: Mutagenicity and reactivity with DNAMutation Research, 1974
- ANGIOSARCOMA OF THE LIVER IN A VINYL-CHLORIDE WORKERThe Lancet, 1974
- Carcinogenicity bioassays of vinyl chlorideEnvironmental Research, 1974
- Dechlorination of chloroethane with a reconstituted liver microsomal systemBiochemical and Biophysical Research Communications, 1973
- Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compoundsCellular and Molecular Life Sciences, 1972
- Fluorescent adenosine and cytidine derivativesBiochemical and Biophysical Research Communications, 1972
- α‐Halogenäther, 41 [1] Zur Existenz von ChloräthylenoxidJournal für Praktische Chemie, 1969