5-HT1A Receptors in major depression
- 1 March 1990
- journal article
- research article
- Published by SAGE Publications in Journal of Psychopharmacology
- Vol. 4 (2), 69-74
- https://doi.org/10.1177/026988119000400204
Abstract
The 5-HT1A receptor has been studied using quantitative tritium film auto radiography in post-mortem frontal cortex of 15 cases suffering from major depression and controls matched for age, sex, post-mortem delay and storage time. 5-HT1A receptor binding in the depressive cohort was not significantly different from control values. No consistent effects of antidepressant medication or mental state at death were seen on the results.Keywords
This publication has 34 references indexed in Scilit:
- Serotonergic measures in the brains of suicide victims: 5-HT2 binding sites in the frontal cortex of suicide victims and control subjectsAmerican Journal of Psychiatry, 1989
- Brain 5-HT2 receptor binding sites in depressed suicide victimsBrain Research, 1988
- Food intake, neuroendocrine and temperature effects of 8-OHDPAT in the ratEuropean Journal of Pharmacology, 1988
- Long‐term imipramine treatment enhances locomotor and food intake suppressant effects of m‐chlorophenylpiperazine in ratsBritish Journal of Pharmacology, 1987
- Serotonin Function and Mechanism of Action of Antidepressant TreatmentArchives of General Psychiatry, 1984
- Receptor Sensitivity and the Mechanism of Action of Antidepressant TreatmentArchives of General Psychiatry, 1981
- Tritiated Imipramine Binding Sites Are Decreased in Platelets of Untreated Depressed PatientsScience, 1980
- "Serotonin Depression"—A Biochemical Subgroup Within the Affective Disorders?Science, 1976
- A Hundred Cases of Suicide: Clinical AspectsThe British Journal of Psychiatry, 1974
- 5-HYDROXYINDOLE COMPOUNDS IN THE CEREBROSPINAL FLUID OF PATIENTS WITH PSYCHIATRIC OR NEUROLOGICAL DISEASESThe Lancet, 1966