Observations on Mechanism of Potassium Excretion due to Administration of Hydrochlorothiazide

Abstract

Potassium excretion with hydrochlorothiazide in adrenalectomized rats was significantly influenced by the presence of small amounts of desoxycorticosterone. Hydrochlorothiazide alone caused kaliuresis only at relatively large doses. These studies demonstrate that potassium loss with thiazide diuretics is in part dependent upon body fluid titers of aldosterone-like steroids.