Depressed monocyte production of interleukin-1 and tumor necrosis factor-alpha in patients with alcoholic liver cirrhosis
- 1 October 1989
- journal article
- research article
- Published by Wiley in Liver International
- Vol. 9 (5), 302-306
- https://doi.org/10.1111/j.1600-0676.1989.tb00415.x
Abstract
— Interleukin‐1 and tumor necrosis factor‐alpha activity by E. coli lipopolysaccharide‐triggered monocytes were studied in patients with chronic alcoholic liver disease. Monocytes from cirrhotic patients were shown to have a significant reduction in IL‐1 and TNF‐a activity, compared with that from age‐ and sex‐matched healthy controls. These findings indicate further immunoregulatory disturbances concerning alcoholic liver cirrhosis.Keywords
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