In recent years, with the advent of newer knowledge concerning vitamins, hormones and the autonomic nervous system, many clinicians have shown renewed interest in the problem of the pathogenesis of retinitis pigmentosa. As a result patients with this disease have been gorged with vitamins, plied with hormones and subjected to cervical sympathectomy in an effort to arrest or cure the condition. Without wishing to be therapeutic nihilists, we believe that these efforts have been misguided. This belief has been reenforced by a study of the Laurence-Moon-Biedl syndrome in 2 instances. In view of the fact that classic examples of the Laurence-Moon-Biedl syndrome are so rare as to be of great interest and are full of significant implications with regard to the polyglandular and retinal manifestations, it is felt that these cases are worthy of report. REPORT OF CASES Case 1.—A. Z., a 12 year old white Cuban boy, was referred