Toward a biochemical classification of depressive disorders, V: Heterogeneity of unipolar depressions
- 1 April 1982
- journal article
- research article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 139 (4), 471-475
- https://doi.org/10.1176/ajp.139.4.471
Abstract
The mean urinary level of 3-methoxy-4-hydorxyphenylglycol (MHPG) was significantly lower in 20 patients with bipolar manic-depressive or schizoaffective depressions than in either 50 patients with unipolar depressions or 26 age- and sex-matched control subjects. The mean MHPG levels in the total group of patients with unipolar depressions and in any subgroups defined by Research Diagnostic Criteria (RDC) were not significantly different from control values. Examination of the distribution of urinary MHPG levels in patients with unipolar depressions in relation to other recent findings by the authors'' collaborative research group suggested the existence of at least three biochemical subtypes of unipolar depressions that may, in part, be differentiated on the basis of urinary MHPG levels.This publication has 23 references indexed in Scilit:
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