On the efficacy of ready-made-up commercially available salicylazosulphapyridine enemas in the treatment of proctitis, proctosigmoiditis and ulcerative colitis involving rectum, sigmoid and descending colon.

Abstract

To investigate efficacy and possible side effects, double-blind studies were carried out using 3% salicylazosulphapyridine enemas and appropriate placebo enemas. In a first study involving peranal therapy along, the success rate was 73%; in a second study employing a combination of oral and peranal medication, the success rate was 75%. This shows that the efficacy of the peranal form of administration is comparable to that obtained with oral medication. No side effects were observed throughout the period of observation of this study.