The effect of SKF 525A (2-diethylaminoethyl 2:2-diphenylvalerate hydrochloride) on organophosphate metabolism in insects and mammals

Abstract

SKF 525 A (2-diethylaminoethyl 2,2-diphenylvalerate hydrochloride) protects mice against poisoning by the 3 phosphorodiamidic compounds tested. Of the 8 phosphorothionates tested, protection against dimethoate only was observed. With houseflies and American cockroaches, SKF 525 A gave no protection against any phosphorothionates. SKF 525 A inhibited the conversion of parathion into paraoxon by mouse-liver slices or cockroach guts. SKF 525 A inhibited the "activation" of schradan by cockroach guts, as had previously been shown for rat-liver preparations. With mice and cockroaches in vivo, SKF 525 A increased the concentration of paraoxon caused by the injection of parathion, and reduced the degradation of injected paraoxon. It was concluded that the diverse effects of SKF 525 A on organophosphate toxicity in various species were due to the variations in the importance of inhibition of "activating" as opposed to degrading enzymes.