IMMUNOSUPPRESSION IN MURINE MALARIA .1. RESPONSE TO TYPE-3 PNEUMOCOCCAL POLYSACCHARIDE
- 1 January 1977
- journal article
- research article
- Vol. 32 (5), 635-644
Abstract
Acute Plasmodium yoelii yoelli and chronic P. berghei malaria infections of CBA mice were accompanied by a reduced capacity to give an antibody response to type III pneumococcal polysaccharide (SIII). The depression of response initiated by acute malaria persisted for several weeks after recovery from clinical infection. During chronic infection, and at the peak of acute parasitemia, virtually no response to SIII was detected. A substance which cross-reacted serologically with SIII was found in blood cells of infected mice. The results suggest that antigen-specific, as well as non-specific, factors may contribute to the depression of the response to this antigen.This publication has 32 references indexed in Scilit:
- KINETICS OF ANTIBODY-RESPONSE TO TYPE-3 PNEUMOCOCCAL POLYSACCHARIDE .3. EVIDENCE THAT SUPPRESSOR CELLS FUNCTION BY INHIBITING RECRUITMENT AND PROLIFERATION OF ANTIBODY-PRODUCING CELLS1976
- Kinetics of the antibody response to type III pneumococcal polysaccharide (SSS-III). I. Use of 125I-labeled SSS-III to study serum antibody levels, as well as the distribution and excretion of antigen after immunization.1976
- Kinetics of the antibody response to type III pneumococcal polysaccharide. II. Factors influencing the serum antibody levels after immunization with an optimally immunogenic dose of antigen.1976
- Homeostatic Control of Antibody Responses: A Model Based on the Recognition of Cell-Associated Antibody by Regulatory T CellsImmunological Reviews, 1975
- Immunosuppressive effects of experimental infection with Plasmodium gallinaceum.1975
- IMMUNOSUPPRESSION IN CHILDREN WITH MALARIAThe Lancet, 1972
- Immunosuppression in murine malaria. II. The effect on reticulo-endothelial and germinal centre function.1971
- Immunosuppression in murine malaria. I. General characteristics.1971
- The significance of multiple antibody components in serum of immunized rabbits.1960
- The Cellular Reactions to Infections with Plasmodium Berghei in the White MouseThe Journal of Infectious Diseases, 1954