The administration of triethylene melamine (TEM) in various hematological disorders has led to the widespread use of this drug since it was introduced in 1951.1 The usual side-effects have been manifested by a toxic depression of the marrow, i. e., anemia, thrombocytopenia, leukopenia, and gastrointestinal disturbances, with nausea and vomiting. We wish to present what appears to be the first recorded instance of a dermatitis due to such therapy. REPORT OF A CASE A 57-year-old white woman was admitted to the Albert Einstein Medical Center, Southern Division, Medical Service No. 1, because of weakness of six months' duration associated with a 50 lb. (22.7 kg.) weight loss. Dyspnea on exertion was recently noted. Fever and night sweats were not present. Physical examination revealed blood pressure to be 132/80 mm. Hg, pulse 82, respirations 18, and temperature 98.6 F. There was no pallor, icterus, splenomegaly, purpura, or glossitis. Generalized adenopathy