Apha‐adrenergic receptor blockade increases human REM sleep.
- 1 April 1975
- journal article
- clinical trial
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 2 (2), 107-110
- https://doi.org/10.1111/j.1365-2125.1975.tb01565.x
Abstract
1 An alpha‐adrenergic receptor blocking agent, thymoxamine (150 mg i.v.) in the early night sleep of young adults increased REM sleep duration and also brief awakenings in the early night, while slow wave sleep, stage 3+4, was diminished. In the later night, however, stage 3+4 sleep was increased. Control experiments demonstrated that thymoxamine (i.v.) was without effect on blood pressure. 2 REM sleep duration may be inversely proportional to noradrenaline available at central alpha‐adrenoceptors, but the control mechanisms for REM sleep appear interdependent with those for NREM sleep.Keywords
This publication has 13 references indexed in Scilit:
- The Effects of Coffee and Napping on Nighttime Highway DrivingAnnals of Internal Medicine, 2006
- Desynchronized sleep and MHPG excretion: an inverse correlationBrain Research, 1973
- Effects of alpha-methyltyrosine on REM sleep and brain amine levels in the cat.1973
- Effects of α-adrenergic blockers on visual evoked responses in rabbitsElectroencephalography and Clinical Neurophysiology, 1972
- Changes During Weeks in Effects of Tricyclic Drugs on the Human Sleeping BrainThe British Journal of Psychiatry, 1972
- Effects of 6-Hydroxydopamine on Sleep in the RatNature, 1971
- Brain Catecholamines and Human SleepNature, 1971
- Adrenergic Blockade and the Corticosteroid and Growth Hormone Responses to MethylamphetamineNature, 1970
- Mono-amine oxidase inhibitors, sleep and moodElectroencephalography and Clinical Neurophysiology, 1970
- Competitive blockade of adrenergic α-receptors and histamine receptors by thymoxamineJournal of Pharmacy and Pharmacology, 1965