Protective Tumor Immunity Induced by Potassium Chloride Extracts of Guinea Pig Hepatomas

Abstract

Tumor-specific antigens of cells of diethylnitrosamine-induced hepatomas in strain-2 guinea pigs were extracted with 3 M KCI. Immunization of normal animals with the extracted tumor antigens in adjuvant protected them against a subsequent challenge with viable tumor cells. Extracted tumor-specific antigens were less effective immunogens than viable tumor cells for both of two antigenically distinct lines.