Molecular cloning of a protective antigen of schistosomes
- 1 March 1987
- journal article
- Published by Springer Nature in Nature
- Vol. 326 (6109), 149-153
- https://doi.org/10.1038/326149a0
Abstract
The complementary DNA sequence encoding the Mr 28,000 antigen of Schistosoma mansoni has been isolated and expressed in Escherichia coli. Experimental vaccination of rats, hamsters and monkeys with a recombinant fusion protein induces a strongly cytotoxic antibody response. Immunization of rats and hamsters with this protein leads to significant protection against a natural challenge infection with live cercariae.Keywords
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