Distribution of Se75 in Serum Proteins of Chicks and Influence of Selenium on Albumin Recovery.

Abstract

Summary Se⁷⁵ was orally administered to 3-week-old chicks fed either selenium deficient or supplemented diets. Distribution of Se⁷⁵ in serum proteins with time and its effect on serum protein pattern were determined electrophoretically. Selenium in the diet had no effect on the distribution of Se⁷⁵ in the protein fraction, but markedly decreased its retention. After 2 hours the major portion of the dose was found in the beta and gamma fraction and the activity in this fraction increased with time. Marked increases in A/G ratios in depleted chicks were observed within 96 hours after administration of Se⁷⁵. Albumin was increased and globulin fractions were decreased. Increases in A/G ratios, somewhat smaller in magnitude, were also noted in chicks receiving a diet supplemented with selenium.