Studies on the metabolism of progesterone and related steroids in vitro. 2. Factors influencing the metabolism of pregnane-3α:20α-diol by rat-liver homogenates, and the investigation of the products of metabolism
- 1 June 1952
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 51 (3), 358-362
- https://doi.org/10.1042/bj0510358
Abstract
It has been shown that coenzyme I is required by an enzyme system or systems in rat-liver homogenates, which are able to metabolize pregnane-3 [alpha]: 20 [alpha]-diol. In a large scale expt. 50% of the pregnane-3 [alpha] ; 20 [alpha] -diol incubated with rat-liver homogenate was metabolized. Of this amt. 10% was recovered as crystalline pregnane-3 [alpha] -ol-20-one. No other crystalline products of the metabolism of pregnanediol were obtained.Keywords
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