A REVIEW of all the cases of leiomyosarcoma of the stomach at the Mayo Clinic has been made, first, because of the apparent increase of the frequency of this condition and, secondly, in order to review again the symptoms and pathologic findings associated with leiomyosarcomas of the stomach. We also wish to present data on a comparatively rare case of multiple leiomyosarcomas of the stomach with metastasis. The relative infrequency of leiomyosarcoma will be seen when one compares the number of cases of surgically verified gastric carcinoma encountered at the clinic in the period 1907 through 1946, i.e., 10,000, with the number of cases of surgically verified leiomyosarcoma of the stomach, i.e., 16. This is a ratio of 625:1. However, the relative frequency of proved cases of this disease is increasing. In the ten year period from 1910 through 1919 it was found in 2 cases at the time of