The Effect of Adrenaline, Noradrenaline, and Propranolol on Myocardial Blood Flow and Metabolic Heat Production in Monkeys and Baboons

Abstract

The effects of adrenaline and noradrenaline on myocardial blood flow and metabolic heat production in monkeys and baboons were studied before and after propranolol. After β-adrenotropic blockade, the action of catecholamines on myocardial vascular resistance was reduced or reversed. Adrenaline-induced changes in “corrected temperature” (an index of local metabolic heat production) were markedly reduced by propranolol. It is suggested that this may be related to the beneficial effects of this drug in angina.