The channel of death
Open Access
- 26 November 2001
- journal article
- editorial
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 155 (5), 695-698
- https://doi.org/10.1083/jcb.200110147
Abstract
The proapoptotic members of the Bcl-2 family have been proposed to participate in the formation of a channel that releases these apoptogenic factors when mitochondria receive apoptotic signals. A recent study provides the first direct, biophysical measurement of a potentially apoptosis-specific mitochondrial channel, which is regulated by Bcl-2 family members and may play a primary role in the release of the proapoptotic factors.Keywords
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