Pyrazolotriazines: a new class of tumour-inhibitory agents
- 1 December 1966
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 18 (Supplement), 1S-4S
- https://doi.org/10.1111/j.2042-7158.1966.tb07950.x
Abstract
A series of pyrazolo-as-triazines have been screened for tumour-inhibitory activity against sarcoma S 180 in mice and a methylcholanthrene-induced tumour in rats. The antitumour activities of ethyl 4-aminopyrazolo[3,2-c]-as-triazine-3-carboxylate (Ig), 6-acetyl- and 6-iodoacetyl-3-methyl-4-methylenepyrazolo[3,2-c]-as-triazine (IIa and IIb respectively) against sarcoma S 180 exceed the inhibitory activity of 6-mercaptopurine against the same tumour.This publication has 2 references indexed in Scilit:
- Antitumor Activity and Structural Relationships of Purine Derivatives and Related Compounds against Neoplasms in Experimental AnimalsJournal of Medicinal Chemistry, 1964
- Immunity to Transplanted Tumour: The Effect of Tumour Extracts on the Growth of Homologous Tumours in RatsBritish Journal of Cancer, 1955