NATURAL-KILLER CELL-FUNCTION OF HUMAN NEONATAL LYMPHOCYTES
- 1 January 1982
- journal article
- research article
- Vol. 48 (3), 649-654
Abstract
Human and natural killer cell (NK cell) activity against human lymphoblastoid K-562 target cell line was evaluated in full term cord blood (n = 30) and adult peripheral blood (n = 20) using 51Cr release assay. The level of NK cell activity was lower in cord blood compared to adult controls (39.6 .+-. 11.4% vs. 27.4 .+-. 11.8% at effector:target ratio 50:1). Adult males showed a significantly higher NK activity compared to females. No sex difference was observed in cord blood. Partially purified human leukocyte interferon (IFN.alpha.) increased in vitro NK cell function of both adult and newborn lymphocytes. The appearance and maturation of human NK cells apparently occur during the intrauterine life of the human fetus.This publication has 29 references indexed in Scilit:
- Interferon induction of natural killer cytotoxicity in human neonatesThe Journal of Pediatrics, 1981
- Low natural in vivo resistance to syngeneic leukaemias in natural killer-deficient miceNature, 1980
- Role of NK cells in tumour growth and metastasis in beige miceNature, 1980
- A new immunodeficiency disorder in humans involving NK cellsNature, 1980
- Cytotoxicity from cultured cells: Analysis of precursors involved in generation of human cells mediating natural and antibody-dependent cell-mediated cytotoxicityCellular Immunology, 1979
- Enhancement by interferon of natural cytotoxic activities of lymphocytes from human cord blood and peripheral blood of aged personsCellular Immunology, 1979
- Large-scale Production of Human Leukocyte Interferon Containing 108 Units per mlJournal of General Virology, 1978
- Human natural cell-mediated cytotoxicity against fetal fibroblastsCellular Immunology, 1977
- Cell-mediated lympholysis by human neonatal lymphocytesClinical Immunology and Immunopathology, 1976
- Lymphotoxin production and blast cell transformation by cord blood lymphocytes: Dissociated lymphocyte function in newborn infantsCellular Immunology, 1974