Reticulo-endothelial function in rats with obstructive jaundice

Abstract

Reticulo‐endothelial function was evaluated by measuring the biokinetics of a standardized ^99mTc‐sulphur colloid using scintillation camera technique in rats with biliary obstruction. There was no difference in the uptake of the colloid in the liver (K₁) between sham operation and biliary obstruction at 1 week and 3 weeks. However, when corrected for changes in liver volume, the corrected colloidal uptake rate (cK₁) of the liver was significantly decreased in 1 week's biliary obstruction (P2) was significantly increased (P99mTc‐sulphur colloid in 3 weeks' biliary obstruction was significantly decreased in both total organ basis and per gram basis (P<0.005). The results demonstrated a depression of RE activity of the liver in biliary obstruction.