Introduction Cryoglobulinemia refers to the presence of a cold-precipitable protein in the serum and is usually characterized clinically by sensitivity to cold, as manifested by Raynaud's phenomenon, purpura, urticaria, ulceration of the skin, peripheral gangrene, and retinal vascular stasis. Increased viscosity of the serum, rouleaux formation, pseudoagglutination of red cells, and an elevated erythrocyte sedimentation rate are common. It may be primary or secondary to many disorders of the reticuloendothelial system. Symptoms may be present when the cryoglobulin concentration is minimal.1 Reticulohistiocytosis, more recently referred to as lipoid dermatoarthritis, is characterized by wide-spread papular and nodular cutaneous eruptions and severe, often mutilating, polyarthritis with circumscribed areas of bone destruction. Lipoidladen giant histiocytes are present in both the skin and synovial tissues. The blood lipid level may be normal or slightly elevated. Tendon sheath swelling and xanthelasma have been reported.2,3 Since corneal opacities have not been reported in either