Pseudohypoparathyroidism and Bone Demineralization: Case Report and Metabolic Studies

Abstract

An 8-yr.-oid white boy with the full-blown picture of pseudohypoparathyroidism associated with radiological evidence of bone demineralization and increased serum alkaline phosphatase is described. Metabolic studies suggest high bone calcium uptake and renal tubular phosphate handling which is completely unrelated to both exogenous and endogenous parathyroid hormones. Serum and urinary calcium and phosphorus became normal after A. T. 10 treatment; however, bone alterations did not change. The hypothesis of an excess of one or more parathyroid hormones is put forward.