THE EFFECTS OF DRUGS ON THE PRODUCTION AND RECOVERY PROCESSES OF THE STRESS ULCER

Abstract

A method for estimating the curative effects of drugs on the gastric ulcer of the rat was deviced. The method was able to produce the comparatively deep ulcer at the glandular portion of the rat stomach under rather physiological condition. The effect of several drugs was examined by this method. On the preventive test an anticholinergic drug, atropine methylbromide, showed the most excellent effect but it had only weak effect on existing ulcer. However, on the curative test glutamine and gefarnate which were almost ineffective on the preventive test were more effective than antacids and the anticholinergic drug. Those drugs seemed to accelerate the repairing of the deficit mucosa without inhibition of the gastric secretion and motility.