REFRACTORINESS TO ANAPHYLACTIC SHOCK AFTER CONTINUOUS FEEDING OF COWS MILK TO GUINEA-PIGS

Abstract

Further studies were undertaken on the anaphylactic sensitization to cows''s milk in guinea-pigs given cows'' milk to drink instead of water. With continuous feeding over a prolonged period of time (over 70 days), about 70% of the guinea-pigs became refractory to intratracheal challenge of cows'' milk and about 30% to i.v. challenge. Some guinea-pigs given cows'' milk from the 2nd day of life appeared not to undergo an early sensitization at all and were probably displaying a tolerance to anaphylactic sensitization. The degree to which this was shown may be genetic. The anaphylactic sensitivity, particularly as regards i.v. challenge, could be assessed by examining the sera for Ig[immunoglobulin]Gla antibiodies to cows'' milk by passive cutaneous anaphylaxis.