Lathyrus Factor Activity of Beta-Aminopropionitrile and Related Compounds.

Abstract

Seventy-seven Sprague-Dawley rats of both sexes weighing 37-54 g were used in separate assays of toxicity of beta-aminopropionitrile (NH2CH2CH2CN) or its analogs. These were added in concentrations of 0.15-0.35% to 1 of 3 diets. Beta-aminopropionitrile (BAPN) produced all the changes observed in rats fed 50% Lathyrus odoratus pea meal. None of the supplements fed with BAPN inhibited the development of skeletal deformities. Substitution of a methyl or acetyl in the amino group or a substitution of OH for the amino group resulted in a loss of activity. Unlike BAPN which principally modifies bone development and produces marked skeletal deformity, Bis-beta-(cyanoethyl)-amine exerts an early and pronounced influence on the central nervous system and subsequently produces lesser skeletal alterations.