Vitamin A Intoxication

Abstract

INTOXICATION from overdosage of vitamin A is suggested by the following recognized signs and symptoms: anorexia, irritability, generalized pruritus, painful extremities, arthralgia and sparse, coarse hair.¹ Hepatomegaly and splenomegaly coupled with hypoplastic anemia, clubbing of fingers, and an abnormal appetite for butter and fish oils have been recorded. It is interesting that similar symptoms develop in rats given toxic doses of vitamin A. The fact that until recently vitamin A intoxication has been reported only in infants and children is not surprising; it is this group that receives supplemental vitamin A in a variety of fish oils or concentrates. The . . .